miR‑199a‑3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells
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منابع مشابه
The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
The transcription factor c-Myc plays critical roles in cancer development and progression through regulating expression of targeted genes. Lactate dehydrogenase A (LDHA), which catalyzes the conversion of L-lactate to pyruvate in the final step of anaerobic glycolysis, is frequently upregulated in pancreatic cancer. However, little is known about the effects of c-Myc-LDHA axis in the progressio...
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Previous investigations from this laboratory have revealed that the over-all oxidative capacity of tumor tissues, in general, falls in the range of the less active normal tissues and at a level much lower than normal liver, kidney, heart, or brain (12), while the enzymes of the glycolytic system occur in quantities of the same order of magnitude in all these tissues (5, 6). Since the conclusion...
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Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this Mini Review, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2018
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2018.3771